Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning

@inproceedings{Bell2011ActivationON,
  title={Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning},
  author={Karen F. S. Bell and Jill H. Fowler and Bashayer Al-Mubarak and Karen Horsburgh and Giles E Hardingham},
  booktitle={Oxidative medicine and cellular longevity},
  year={2011}
}
Prophylactic pharmacological activation of astrocytic gene expression driven by the transcription factor Nrf2 boosts antioxidant defences and protects against neuronal loss in ischemia and other disease models. However, the role of Nrf2 in mediating endogenous neuroprotective responses is less clear. We recently showed that Nrf2 is activated by mild oxidative stress in both rodent and human astrocytes. Moreover, brief exposure to ischemic conditions was found to activate Nrf2 both in vivo and… CONTINUE READING
27 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…