Activation of Na+/K+-ATPase by the Serum and Glucocorticoid-Dependent Kinase Isoforms

  title={Activation of Na+/K+-ATPase by the Serum and Glucocorticoid-Dependent Kinase Isoforms},
  author={Guido Henke and Iwan Setiawan and Christoph B{\"o}hmer and Florian Lang},
  journal={Kidney and Blood Pressure Research},
  pages={370 - 374}
Background/Aim: Expression of the constitutively active form of serum and glucocorticoid-dependent kinase (<sup>S422D</sup>SGK1) in Xenopus oocytes has recently been shown to upregulate endogenous Na<sup>+</sup>/K<sup>+</sup>-ATPase activity, an effect presumably participating in the regulation of cellular K<sup>+</sup> uptake and transepithelial Na<sup>+</sup> transport. SGK1 and the two isoforms SGK2 and SGK3 are stimulated by insulin and insulin-like growth factor-1 (IGF-1), which have been… 

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