Activation of NR2A receptors induces ischemic tolerance through CREB signaling.

  title={Activation of NR2A receptors induces ischemic tolerance through CREB signaling.},
  author={Yasukazu Terasaki and Tsutomu Sasaki and Yoshiki Yagita and Shuhei Okazaki and Yukio Sugiyama and Naoki Oyama and Emi Omura-Matsuoka and Saburo Sakoda and Kazuo Kitagawa},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={30 8},
Previous exposure to a nonlethal ischemic insult protects the brain against subsequent harmful ischemia. N-methyl-D-aspartate (NMDA) receptors are a highly studied target of neuroprotection after ischemia. Recently, NMDA receptor subtypes were implicated in neuronal survival and death. We focused on the contribution of NR2A and cyclic-AMP response element (CRE)-binding protein (CREB) signaling to ischemic tolerance using primary cortical neurons. Ischemia in vitro was modeled by oxygen-glucose… CONTINUE READING


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