Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation.

@article{Weitlauf2005ActivationON,
  title={Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation.},
  author={Carl Weitlauf and Yumiko Honse and Yves P Auberson and Masayoshi Mishina and David M. Lovinger and Danny G. Winder},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 37},
  pages={8386-90}
}
Activation of NMDA receptors (NMDARs) within the CNS represents a major signal for persistent alterations in glutamatergic signaling, such as long-term potentiation (LTP) and long-term depression. NMDARs are composed of a combination of NR1 and NR2 subunits, with distinct NR2 subunits imparting distinct characteristics on the receptor. One particular NR2 subunit, NR2A (NRepsilon1), has been proposed to play an integral role in LTP induction in the hippocampus and cortex. Here, we report studies… CONTINUE READING
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