Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells.

@article{Joo2007ActivationON,
  title={Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells.},
  author={Jae-Yeol Joo and B. Kim and J Lee and Jin-Yong Park and Sunoh Kim and Young-Joo Yun and Sang-Hun Lee and Suk-Ho Lee and Hyewhon Rhim and Hyeon Son},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 8},
  pages={1358-70}
}
The prolonged effects of N-methyl-D-aspartate (NMDA) receptor activation on the proliferation and differentiation of hippocampal neural progenitor cells (NPCs) were studied. Under conditions of mitogen-mediated proliferation, a single NMDA pulse (5 microM) increased the fraction of 5-bromo-2-deoxyuridine (BrdU)-positive (BrdU(+)) cells after a delay of 72 hours. Similarly, a single systemic injection of NMDA (100 mg/kg) increased the number of BrdU(+) cells in the dentate gyrus (DG) after 28… CONTINUE READING

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