Activation of NMDA receptors elecits fictive locomotion and bistable membrane properties in the lamprey spinal cord

@article{Sigvardt1985ActivationON,
  title={Activation of NMDA receptors elecits fictive locomotion and bistable membrane properties in the lamprey spinal cord},
  author={Karen A. Sigvardt and Sten Grillner and Peter Wall{\'e}n and Paul A. M. van Dongen},
  journal={Brain Research},
  year={1985},
  volume={336},
  pages={390-395}
}
The motor pattern underlying locomotion in the lamprey can be elicited in the spinal cord in vitro by applying excitatory amino acids that activate NMDA receptors. When this is done oscillatory membrane potentials phase-linked with the locomotory rhythm can be recorded in different types of neurones. In some spinal neurones large amplitude oscillation continues after elimination of synaptic input with application of TTX. This oscillatory pacemaker-like activity is dependent on an activation of… CONTINUE READING

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