Activation of NKT cells protects mice from tuberculosis.

  title={Activation of NKT cells protects mice from tuberculosis.},
  author={Alissa A. Chackerian and Jen Alt and V. J. O. Perera and Samuel M Behar},
  journal={Infection and immunity},
  volume={70 11},
The T-cell immune response to Mycobacterium tuberculosis is critical in preventing clinical disease. While it is generally accepted that both major histocompatibility complex class I (MHC-I)-restricted CD8(+) and MHC-II-restricted CD4(+) T cells are important for the immune response to M. tuberculosis, the role of non-MHC-restricted T cells is still not clearly delineated. We have previously reported that CD1d(-/-) mice do not differ from CD1d(+/+) mice in their survival following infection… CONTINUE READING
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