Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1.

@article{Wang2005ActivationON,
  title={Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1.},
  author={Dongsheng Wang and Hong Sun and Florian Lang and C H Chris Yun},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={289 4},
  pages={C802-10}
}
Glucocorticoids stimulate Na+ absorption by activation of the epithelial Na+/H+ exchanger NHE3 in the kidney and intestine. It has been thought that glucocorticoid-induced activation of NHE3 is solely dependent on transcriptional induction of the NHE3 gene. While the transcriptional regulation remains an essential part of the chronic effect of glucocorticoids, a previous study by us identified the serum- and glucocorticoid-inducible kinase 1 (SGK1) as an important component of the activation of… CONTINUE READING

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