Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival.

@article{Song2008ActivationON,
  title={Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival.},
  author={Jianxun Song and Takanori So and Michael Croft},
  journal={Journal of immunology},
  year={2008},
  volume={180 11},
  pages={7240-8}
}
The costimulatory molecule OX40 (CD134) is required in many instances for effective T cell-mediated immunity, controlling proliferation, and survival of T cells after encountering specific Ag. We previously found that the functional targets of OX40 are survivin and aurora B that regulate proliferation and Bcl-2 antiapoptotic family members that regulate survival. However, the intracellular pathways from OX40 that mediate these effects are unclear. In this study, we show that OX40 signaling can… CONTINUE READING

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