Activation of NF-kappaB nuclear transcription factor by flow in human endothelial cells.

@article{Hay2003ActivationON,
  title={Activation of NF-kappaB nuclear transcription factor by flow in human endothelial cells.},
  author={David C. Hay and Catherine Beers and V. Cameron and Lesley Thomson and Frederick Werner Flitney and Ronald Thomas Hay},
  journal={Biochimica et biophysica acta},
  year={2003},
  volume={1642 1-2},
  pages={33-44}
}
The tractive force generated by blood flow, called fluid shear stress, is an important regulator of endothelial cell gene expression. Several transcription factors are activated by shear stress, including members of the NF-kappaB/Rel family. The nature of the upstream-signaling components involved in the activation of NF-kappaB by flow has been studied in human endothelial cells. Flow rapidly increased endogenous IKK1/2 activity and transiently degraded IkappaBalpha and IkappaBbeta1, but not… CONTINUE READING
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