Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis.

@article{Mller2002ActivationON,
  title={Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis.},
  author={Markus M{\"u}ller and Alessandro Morotti and Carola Ponzetto},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 4},
  pages={1060-72}
}
Hepatocyte growth factor (HGF) and its receptor, Met, regulate a number of biological functions in epithelial and nonepithelial cells, such as survival, motility, proliferation, and tubular morphogenesis. The transcription factor NF-kappaB is activated in response to a wide variety of stimuli, including growth factors, and is involved in biological responses in part overlapping with those triggered by HGF. In this work we used the liver-derived MLP29 cell line to study the possible involvement… CONTINUE READING
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