Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation.

@article{Maloney2009ActivationON,
  title={Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation.},
  author={Ezekiel Maloney and Ian R Sweet and David M. Hockenbery and Matilda Pham and Norma O. Rizzo and Sanshiro Tateya and Priya Handa and Michael W Schwartz and Francis Kim},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 9},
  pages={
          1370-5
        }
}
OBJECTIVE We investigated whether NADPH oxidase-dependent production of superoxide contributes to activation of NF-kappaB in endothelial cells by the saturated free fatty acid palmitate. METHODS AND RESULTS After incubation of human endothelial cells with palmitate at a concentration known to induce cellular inflammation (100 mumol/L), we measured superoxide levels by using electron spin resonance spectroscopy and the spin trap 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (CMH… CONTINUE READING
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