Activation of NF-κB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP+ toxicity in SK-N-SH cells

@article{Sarnico2007ActivationON,
  title={Activation of NF-κB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP+ toxicity in SK-N-SH cells},
  author={Ilenia Sarnico and Flora Boroni and Marina Benarese and Sandra Sigala and Annamaria Lanzillotta and Leontino Battistin and PierFranco Spano and Marina Pizzi},
  journal={Journal of Neural Transmission},
  year={2007},
  volume={115},
  pages={669-676}
}
Nuclear factor-κB (NF-κB) is a transcriptional regulator of neuron survival eliciting diverse effects according to the specific composition of its active dimer. While p50/p65 mediates neurodegenerative events, c-Rel-containing dimers promote cell survival. Stimulation of metabotropic glutamate receptors type 5 (mGlu5) reduces neuron vulnerability to amyloid-β through activation of anti-apoptotic, c-Rel-dependent transcription of Bcl-XL pathway. We here evaluated the protective activity of mGlu5… CONTINUE READING

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