Activation of NADPH oxidases leads to DNA damage in esophageal cells

Abstract

Gastroesophageal reflux disease (GERD) is the strongest known risk factor for esophageal adenocarcinoma. In the center of tumorigenic events caused by GERD is repeated damage of esophageal tissues by the refluxate. In this study, we focused on a genotoxic aspect of exposure of esophageal cells to acidic bile reflux (BA/A). Analyzing cells generated from… (More)
DOI: 10.1038/s41598-017-09620-4

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