Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid.

@article{Cherny2001ActivationON,
  title={Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid.},
  author={Vladimir Cherny and L M Henderson and Wei Xu and Larry L. Thomas and Thomas E DeCoursey},
  journal={The Journal of physiology},
  year={2001},
  volume={535 Pt 3},
  pages={783-94}
}
1. Effects of arachidonic acid (AA) on proton and electron currents in human eosinophils were studied using the permeabilized-patch voltage-clamp technique, using an applied NH4+ gradient to control pH(i). 2. Superoxide anion (O2-) release was assessed by cytochrome c reduction in human eosinophils. Significant O2- release was stimulated by 5-10 microM AA. 3. AA activated diphenylene iodinium (DPI)-inhibitable inward current reflecting electron efflux through NADPH oxidase. These electron… CONTINUE READING

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