Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox.

@article{Dusi1993ActivationON,
  title={Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox.},
  author={Stefano Dusi and Filippo Rossi},
  journal={The Biochemical journal},
  year={1993},
  volume={296 ( Pt 2)},
  pages={367-71}
}
Activation of human neutrophil NADPH oxidase requires the interaction of cytosolic and membrane-associated components. Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase. No direct evidence has been presented to date as to whether p67phox is also phosphorylated. To address… CONTINUE READING

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