Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease

@inproceedings{Kurahara2018ActivationOM,
  title={Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease},
  author={Lin Hai Kurahara and K. Hiraishi and Yaopeng Hu and Kaori Koga and Miki Onitsuka and Mayumi Doi and Kunihiko Aoyagi and Hidetoshi Takedatsu and Daibo Kojima and Yoshitaka Fujihara and Yuwen Jian and Ryuji Inoue},
  booktitle={Cellular and molecular gastroenterology and hepatology},
  year={2018}
}
Background & Aims The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear. Here, we evaluated the function of myofibroblast TRPA1 channels in intestinal remodeling. Methods An intestinal myofibroblast cell line (InMyoFibs) was stimulated by transforming growth factor-β1 to induce in vitro fibrosis. Trpa1 knockout mice were generated using the Clustered regularly… CONTINUE READING
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