Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System

@inproceedings{Imbe2011ActivationOM,
  title={Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System},
  author={Hiroki Imbe and Emiko Senba and Akihisa Kimura and Tomohiro Donishi and Isao Yokoi and Yoshiki Kaneoke},
  booktitle={Journal of signal transduction},
  year={2011}
}
The descending pain modulatory system is thought to undergo plastic changes following peripheral tissue injury and exerts bidirectional (facilitatory and inhibitory) influence on spinal nociceptive transmission. The mitogen-activated protein kinases (MAPKs) superfamily consists of four main members: the extracellular signal-regulated protein kinase1/2 (ERK1/2), the c-Jun N-terminal kinases (JNKs), the p38 MAPKs, and the ERK5. MAPKs not only regulate cell proliferation and survival but also play… CONTINUE READING