Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing.

@article{Velasquez2013ActivationOM,
  title={Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing.},
  author={Lissette S Velasquez and Lillian B. Sutherland and Zhenan Liu and Frederick Grinnell and Kristine E. Kamm and Jay W. Schneider and Eric N Olson and Eric M. Small},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 42},
  pages={16850-5}
}
Myocardin-related transcription factors (MRTFs) regulate cellular contractility and motility by associating with serum response factor (SRF) and activating genes involved in cytoskeletal dynamics. We reported previously that MRTF-A contributes to pathological cardiac remodeling by promoting differentiation of fibroblasts to myofibroblasts following myocardial infarction. Here, we show that forced expression of MRTF-A in dermal fibroblasts stimulates contraction of a collagen matrix, whereas… CONTINUE READING

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