Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

@article{Voisin2008ActivationOM,
  title={Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors},
  author={Laure Voisin and Catherine Julien and St{\'e}phanie Duhamel and Kailesh Gopalbhai and Isabelle Claveau and Marc K. Saba-El-Leil and Ian Ga{\"e}l Rodrigue-Gervais and Louis Gaboury and Daniel Lamarre and Mark Basik and Sylvain Meloche},
  journal={BMC Cancer},
  year={2008},
  volume={8},
  pages={337 - 337}
}
The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are therefore viewed as attractive drug candidates for the targeted therapy of this malignancy. However, the exact contribution of MEK1 and MEK2 to the pathogenesis of colorectal cancer remains to be established. Wild type and constitutively active forms of MEK1 and MEK2 were ectopically expressed… CONTINUE READING
30 Citations
59 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

  • G Pearson, F Robinson, +4 authors MH Cobb
  • Endocr Rev
  • 2001
Highly Influential
10 Excerpts

ND: Classification of human colorectal adenocarcinoma cell lines

  • A Leibovitz, JC Stinson, WB 3rdMcCombs, CE McCoy, KC Mazur, Mabry
  • Cancer Res
  • 1976
Highly Influential
9 Excerpts

Similar Papers

Loading similar papers…