Activation of MAPKs in human bronchial epithelial cells exposed to metals.

  title={Activation of MAPKs in human bronchial epithelial cells exposed to metals.},
  author={James M. Samet and Lee M Graves and Jacqueline Quay and Lisa A. Dailey and Robert B. Devlin and Andrew J Ghio and Weidong Wu and Philip A. Bromberg and William Reed},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={275 3},
We have previously shown that in vitro exposure to metallic compounds enhances expression of interleukin (IL)-6, IL-8, and tumor necrosis factor-α in human bronchial epithelial cells. To characterize signaling pathways involved in metal-induced expression of inflammatory mediators and to identify metals that activate them, we studied the effects of As, Cr, Cu, Fe, Ni, V, and Zn on the mitogen-activated protein kinases (MAPK) extracellular receptor kinase (ERK), c-Jun NH2-terminal kinase (JNK… CONTINUE READING

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