Activation of MAPK by modified low-density lipoproteins in vascular smooth muscle cells.

@article{Velarde2001ActivationOM,
  title={Activation of MAPK by modified low-density lipoproteins in vascular smooth muscle cells.},
  author={Victoria Velarde and Alicia Josephine Jenkins and Jennifer Christopher and Timothy J Lyons and Ayad A. Jaffa},
  journal={Journal of applied physiology},
  year={2001},
  volume={91 3},
  pages={1412-20}
}
A high concentration of circulating low-density lipoproteins (LDL) is a major risk factor for atherosclerosis. Native LDL and LDL modified by glycation and/or oxidation are increased in diabetic individuals. LDL directly stimulate vascular smooth muscle cell (VSMC) proliferation; however, the mechanisms remain undefined. The extracellular signal-regulated kinase (ERK) pathway mediates changes in cell function and growth. Therefore, we examined the cellular effects of native and modified LDL on… CONTINUE READING
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