Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves.

@article{Yamazaki2009ActivationOM,
  title={Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves.},
  author={Takashi Yamazaki and Hemragul Sabit and Takeshi Oya and Yoko Ishii and Takeru Hamashima and Ayano Tokunaga and Shin Ishizawa and Shen Jie and Yoichi Kurashige and Toshiya Matsushima and Isao Furuta and Makoto Noguchi and M D Arthur Sasahara},
  journal={Journal of the peripheral nervous system : JPNS},
  year={2009},
  volume={14 3},
  pages={
          165-76
        }
}
A number of receptor tyrosine kinases (RTKs) and the downstream phosphatidylinositol-3-kinase (PI3K)/Akt and mitogen-activated protein (MAP) kinase signaling pathways have been critically involved in peripheral nerve regeneration. Here, we examined the activation of PI3K/Akt and MAP kinase pathways, and platelet-derived growth factor receptors (PDGFRs) in the distal segments of crushed rat sciatic nerve from 3 to 28 days after injury. In Western blot analyses, the phosphorylated forms of… CONTINUE READING
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