Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cells.

@article{Adler2007ActivationOM,
  title={Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cells.},
  author={Henric S. Adler and Sebastian Kubsch and Edith Graulich and Stephan Ludwig and Juergen Knop and Kerstin Steinbrink},
  journal={Blood},
  year={2007},
  volume={109 10},
  pages={4351-9}
}
Regulatory T cells play an essential role in the control of self-tolerance and processes of adaptive immunity. Tolerogenic IL-10-modulated human dendritic cells (IL-10DCs) induce anergic T cells with strong suppressive properties (iTregs) that inhibit the activation of effector T cells. In this study, we evaluated the interaction between cell-cycle regulation and intracellular signaling in these iTregs. Analysis of signal transduction events revealed a down-regulation of the mitogen-activated… CONTINUE READING
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