Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice.

Abstract

BACKGROUND AND PURPOSE The calcium-activated potassium channel KCa3.1 is expressed in the vascular endothelium where its activation causes endothelial hyperpolarization and initiates endothelium-derived hyperpolarization (EDH)-dependent dilatation. Here, we investigated whether pharmacological activation of KCa3.1 dilates skeletal muscle arterioles and… (More)
DOI: 10.1111/bph.12267

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@article{Radtke2013ActivationOK, title={Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice.}, author={Josephine Radtke and Kjestine Schmidt and Heike Wulff and Ralf K{\"o}hler and Cor de Wit}, journal={British journal of pharmacology}, year={2013}, volume={170 2}, pages={293-303} }