Activation of K+ channels induces apoptosis in vascular smooth muscle cells.

  title={Activation of K+ channels induces apoptosis in vascular smooth muscle cells.},
  author={Stefanie Krick and Oleksandr Platoshyn and Meghan Sweeney and H S Kim and J X Yuan},
  journal={American journal of physiology. Cell physiology},
  volume={280 4},
Intracellular K+ plays an important role in controlling the cytoplasmic ion homeostasis for maintaining cell volume and inhibiting apoptotic enzymes in the cytosol and nucleus. Cytoplasmic K+ concentration is mainly regulated by K+ uptake via Na+-K+-ATPase and K+ efflux through K+ channels in the plasma membrane. Carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP), a protonophore that dissipates the H+ gradient across the inner membrane of mitochondria, induces apoptosis in many cell… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 70 extracted citations

Regulation and critical role of potassium homeostasis in apoptosis

Progress in Neurobiology • 2003
View 3 Excerpts
Highly Influenced

Roles of K+ channels in regulating tumour cell proliferation and apoptosis

Pflügers Archiv • 2004
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…