Activation of K+ channels induces apoptosis in vascular smooth muscle cells.

@article{Krick2001ActivationOK,
  title={Activation of K+ channels induces apoptosis in vascular smooth muscle cells.},
  author={Stefanie Krick and Oleksandr Platoshyn and Meghan Sweeney and H S Kim and J X Yuan},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={280 4},
  pages={C970-9}
}
Intracellular K+ plays an important role in controlling the cytoplasmic ion homeostasis for maintaining cell volume and inhibiting apoptotic enzymes in the cytosol and nucleus. Cytoplasmic K+ concentration is mainly regulated by K+ uptake via Na+-K+-ATPase and K+ efflux through K+ channels in the plasma membrane. Carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP), a protonophore that dissipates the H+ gradient across the inner membrane of mitochondria, induces apoptosis in many cell… CONTINUE READING

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