Activation of K+ channels by lanthanum contributes to the block of transmitter release in chick and rat sympathetic neurons

@article{Przywara1992ActivationOK,
  title={Activation of K+ channels by lanthanum contributes to the block of transmitter release in chick and rat sympathetic neurons},
  author={Dennis A. Przywara and S. V. Bhave and Anjali Bhave and Pertha S. Chowdhury and Taruna D. Wakade and Arun R. Wakade},
  journal={The Journal of Membrane Biology},
  year={1992},
  volume={125},
  pages={155-162}
}
We studied the effects of lanthanum (La3+) on the release of 3H-norepinephrine(3H-NE), intracellular Ca2+ concentration, and voltage clamped Ca2+ and K+ currents in cultured sympathetic neurons. La3+ (0.1 to 10 μm) produced concentration-dependent inhibition of depolarization induced Ca2+ influx and 3H-NE release. La3+ was more potent and more efficacious in blocking 3H-NE release than the Ca2+-channel blockers cadmium and verapamil, which never blocked more than 70% of the release. At 3 μm… CONTINUE READING

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Activation of K + Channels by Lanthanum and modulation of 3 Hnoradrenaline release in chick sympathetic neurons

  • B. Rudy
  • J . Physiol .
  • 1988

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