Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.

@article{Feng1997ActivationOJ,
  title={Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.},
  author={Jian Feng and Bruce A. Witthuhn and Tadashi Matsuda and F Kohlhuber and Ian M. Kerr and James N. Ihle},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 5},
  pages={2497-501}
}
The Janus protein tyrosine kinases (Jaks) play critical roles in transducing growth and differentiation signals emanating from ligand-activated cytokine receptor complexes. The activation of the Jaks is hypothesized to occur as a consequence of auto- or transphosphorylation on tyrosine residues associated with ligand-induced aggregation of the receptor chains and the associated Jaks. In many kinases, regulation of catalytic activity by phosphorylation occurs on residues within the activation… CONTINUE READING

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