Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure

  title={Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure},
  author={Song Hee Jeon and Yong Sik Kim and C K Bae and Joo-bae Park},
  journal={Experimental & Molecular Medicine},
Kainic acid, an analogue of glutamate, causes limbic seizures and induces cell death in the rat brain. We examined the activation of MAPK family kinases; ERKs, JNKs and p38 kinase in rat hippocampus after KA treatment. Activation of all three kinases were observed at 30 min after the treatment, but, in contrary to ERK phosphorylation, which lasted up to 3 h, the phosphorylation of JNK and p38 returned to the basal level by 2 h. The phosphorylation of' upstream kinases for the MAPK family was… CONTINUE READING


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Kainic acidinduced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms

  • J. Neurochem
  • Neuroscience
  • 2000

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