Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens

BACKGROUND Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases. METHODOLOGY/PRINCIPAL FINDINGS Using patient skin biopsies, cell culture and murine infection models, HIF-1… CONTINUE READING