Activation of Human Monocytes by Live Borrelia burgdorferi Generates TLR2-Dependent and -Independent Responses Which Include Induction of IFN-β

@article{Salazar2009ActivationOH,
  title={Activation of Human Monocytes by Live Borrelia burgdorferi Generates TLR2-Dependent and -Independent Responses Which Include Induction of IFN-β},
  author={Juan P. Salazar and Star Duhnam-Ems and Carson J. La Vake and Adriana Cruz and Meagan W. Moore and Melissa Jo Caimano and Leonor Velez-Climent and Jonathan M Shupe and Winfried Krueger and Justin D. Radolf},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={1093 - 1101}
}
It is widely believed that innate immune responses to Borrelia burgdorferi (Bb) are primarily triggered by the spirochete's outer membrane lipoproteins signaling through cell surface TLR1/2. We recently challenged this notion by demonstrating that phagocytosis of live Bb by peripheral blood mononuclear cells (PBMCs) elicited greater production of proinflammatory cytokines than did equivalent bacterial lysates. Using whole genome microarrays, we show herein that, compared to lysates, live… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection

Infectious diseases and therapy • 2017
View 12 Excerpts
Highly Influenced

Immunostimulation in the era of the metagenome

Cellular and Molecular Immunology • 2011
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 123 references

Distinct roles for MyD88, TLR2, TLR5, and TLR9 in phagocytosis of Borrelia burgdorferi and inflammatory signaling

OS Shin, R Isberg, S Akira, S Uematsu, AK Behera
Infect Immun • 2008
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…