Activation of Hippocampal CREB by Rolipram Partially Recovers Balance Between TNF-α and IL-10 Levels and Improves Cognitive Deficits in Diabetic Rats

@article{Miao2015ActivationOH,
  title={Activation of Hippocampal CREB by Rolipram Partially Recovers Balance Between TNF-α and IL-10 Levels and Improves Cognitive Deficits in Diabetic Rats},
  author={Ya Miao and Ting He and Yitong Zhu and Wei Li and Beiyuan Wang and Yuan Zhong},
  journal={Cellular and Molecular Neurobiology},
  year={2015},
  volume={35},
  pages={1157-1164}
}
Diabetes damages the central nervous system, inducing cognitive dysfunction and structural changes, known as diabetic encephalopathy (DE). Some research suggests that the pathogenesis of DE may involve an inflammatory imbalance in the nervous system, along with β-amyloid deposition, similar to Alzheimer’s disease. Less data have been yet provided to prove that mechanism. The aim of this study was to evaluate the influence of diabetes on the expression of TNF-α, IL-10, and cAMP response element… CONTINUE READING
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