Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation.

@article{PenzoMndez2003ActivationOG,
  title={Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation.},
  author={Alfredo Penzo-M{\'e}ndez and Muriel Umbhauer and Alexandre Djiane and Jean-Claude Boucaut and Jean-François Riou},
  journal={Developmental biology},
  year={2003},
  volume={257 2},
  pages={302-14}
}
Wnt-11/Xfz7 signaling plays a major role in the regulation of convergent extension movements affecting the dorsal marginal zone (DMZ) of gastrulating Xenopus embryos. In order to provide data concerning the molecular targets of Wnt-11/Xfz7 signals, we have analyzed the regulation of the Rho GTPase Cdc42 by Wnt-11. In animal cap ectoderm, Cdc42 activity increases as a response to Wnt-11 expression. This increase is inhibited by pertussis toxin, or sequestration of free Gbetagamma subunits by… CONTINUE READING

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