Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G

@inproceedings{Li2015ActivationOG,
  title={Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G},
  author={Wen G. Li and Zheng Xia Liu and Ravi Kiran Koripella and Robert Langlois and Suparna Sanyal and Joachim Frank},
  booktitle={Science Advances},
  year={2015}
}
During protein synthesis, elongation of the polypeptide chain by each amino acid is followed by a translocation step in which mRNA and transfer RNA (tRNA) are advanced by one codon. This crucial step is catalyzed by elongation factor G (EF-G), a guanosine triphosphatase (GTPase), and accompanied by a rotation between the two ribosomal subunits. A mutant of EF-G, H91A, renders the factor impaired in guanosine triphosphate (GTP) hydrolysis and thereby stabilizes it on the ribosome. We use… CONTINUE READING
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