Activation of GABAA receptors modulates all stages of mechanoreception in spider mechanosensory neurons.

@article{Pfeiffer2012ActivationOG,
  title={Activation of GABAA receptors modulates all stages of mechanoreception in spider mechanosensory neurons.},
  author={Keram Pfeiffer and P{\"a}ivi H. Torkkeli and Andrew S. French},
  journal={Journal of neurophysiology},
  year={2012},
  volume={107 1},
  pages={
          196-204
        }
}
GABA(A) receptors mediate mainly inhibitory effects, but there are also many examples of excitatory effects in both mammalian and invertebrate preparations. Here, we aimed to create a complete, quantitative picture of GABA(A)-mediated excitation in a mechanosensory neuron where this phenomenon has been well established. We used muscimol to activate GABA(A) receptors in spider VS-3 neurons and measured the dynamic behavior independently and separately at each of three stages of mechanoreception… 
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References

SHOWING 1-10 OF 43 REFERENCES
Random stimulation of spider mechanosensory neurons reveals long-lasting excitation by GABA and muscimol.
TLDR
The results show that the VS-3 neuron's response to GABA depends profoundly on the type of signals the neuron is conveying while the transmitter binds to its receptors, and that excitation could override the inhibitory effect produced by increased membrane conductance.
Peripheral GABAergic inhibition of spider mechanosensory afferents
TLDR
Investigation of spider mechanosensory neurons in the slit sense organ VS‐3 shows that GABA can rapidly and selectively inhibit specific mechanoreceptors in the periphery, and argues against previous findings that GABA‐mediated inhibition is caused by a depolarization that inactivates Na+ conductance and supports those findings that assign this role to membrane shunting.
Neuromodulation of arthropod mechanosensory neurons
TLDR
It is demonstrated that sensory signals detected by arthropod mechanosensory neurons can also be synaptically modulated before they ever arrive at the axon terminals, thus reducing the synaptic potentials in the postsynaptic neurons.
GABAergic/Glutamatergic–Glial/Neuronal Interaction Contributes to Rapid Adaptation in Pacinian Corpuscles
TLDR
Together, these results suggest that GABA, emanating from the modified Schwann cells of the capsule, inhibits glutamatergic excitation during the static portion of sustained pressure, thus forming a “mechanochemical,” rather than purely mechanical, rapid adaptation response.
Feedback modulation of transduction by calcium in a spider mechanoreceptor
TLDR
The data indicate that calcium regulates sensitivity in a group of sensory neurons of the spider Cupiennius salei by negative feedback from action potentials onto transduction channels.
Intracellular characterization of identified sensory cells in a new spider mechanoreceptor preparation.
TLDR
An isolated mechanoreceptor-organ preparation in which the intact sensory structures are available for mechanical stimulation and electrical recording offers the possibility of characterizing the mechanisms underlying transduction and adaptation in primary mechanosensory neurons.
Neuromodulation of Spike-Timing Precision in Sensory Neurons
TLDR
It is concluded that spike-timing precision of mechanoreceptor afferents in response to dynamic stimulation can be altered by neuromodulators acting directly on the afferent neurons.
GABAergic Excitation of Spider Mechanoreceptors Increases Information Capacity by Increasing Entropy Rather than Decreasing Jitter
TLDR
The results indicate that the major increase in information capacity by neurotransmitter action arose from the increased entropy rate produced by increased firing rate, not from reduction in membrane noise and action potential jitter.
Contributions of voltage- and Ca2+-activated conductances to GABA-induced depolarization in spider mechanosensory neurons.
TLDR
By blocking Na channels prior to GABA application, it is confirmed experimentally that Na(+) current contributes to GABA-induced depolarization in VS-3 neurons, and data show that GABA(A)-receptor activation participates in this regulation.
Slow adaptation in spider mechanoreceptor neurons
TLDR
A cuticular mechanoreceptor organ of the spider is quantified by stimulating with continuous pseudorandom mechanical displacements while recording action potentials intracellularly from the cell bodies, showing that slow adaptation occurs during action potential encoding from the receptor potential.
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