Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice.

@article{Bortolato2007ActivationOG,
  title={Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice.},
  author={Marco Bortolato and Roberto Frau and Marco Orr{\'u} and Anna Paola Piras and Mauro F{\`a} and Antonella Tuveri and Monica Puligheddu and Gian Luigi Gessa and Maria Paola Castelli and Giampaolo Mereu and Francesco Marrosu},
  journal={Psychopharmacology},
  year={2007},
  volume={194 3},
  pages={361-9}
}
RATIONALE Gamma-amino-butyric acid (GABA)(B) receptors play a key role in the pathophysiology of psychotic disorders. We previously reported that baclofen, the prototypical GABA(B) agonist, elicits antipsychotic-like effects in the rat paradigm of prepulse inhibition (PPI) of the startle, a highly validated animal model of schizophrenia. OBJECTIVES We studied the role of GABA(B) receptors in the spontaneous PPI deficits displayed by DBA/2J mice. MATERIALS AND METHODS We tested the effects… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…