Activation of G-proteins in brain by endogenous and exogenous cannabinoids

@article{Childers2006ActivationOG,
  title={Activation of G-proteins in brain by endogenous and exogenous cannabinoids},
  author={Steven R. Childers},
  journal={The AAPS Journal},
  year={2006},
  volume={8},
  pages={E112-E117}
}
The biological response to cannabinoid agonist begins when the agonist-bound receptor activates G-protein Gα subunits, thus initiating a cascade of signal transduction pathways. For this reason, information about cannabinoid receptors/G-protein coupling is critical to understand both the acute and chronic actions of cannabinoids. This review focuses on these mechanisms, predominantly examining the ability of cannabinoid agonists to activate G-proteins in brain with agonist-stimulated [35S… CONTINUE READING
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Agonist - induced internalization and traf fi cking of cannabinoid CB 1 receptors in hippocampal neurons

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