Activation of G-proteins in brain by endogenous and exogenous cannabinoids

  title={Activation of G-proteins in brain by endogenous and exogenous cannabinoids},
  author={Steven R. Childers},
  journal={The AAPS Journal},
The biological response to cannabinoid agonist begins when the agonist-bound receptor activates G-protein Gα subunits, thus initiating a cascade of signal transduction pathways. For this reason, information about cannabinoid receptors/G-protein coupling is critical to understand both the acute and chronic actions of cannabinoids. This review focuses on these mechanisms, predominantly examining the ability of cannabinoid agonists to activate G-proteins in brain with agonist-stimulated [35S… CONTINUE READING
23 Extracted Citations
53 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 23 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 53 references

Agonist - induced internalization and traf fi cking of cannabinoid CB 1 receptors in hippocampal neurons

  • AA Coutts, S Anavi-Goffer, RA Ross
  • J Neurosci
  • 2001

Similar Papers

Loading similar papers…