Activation of G-protein-coupled receptors: a common molecular mechanism

  title={Activation of G-protein-coupled receptors: a common molecular mechanism},
  author={Sadashiva S Karnik and Camelia Baleanu Gogonea and Supriya Patil and Yasser Saad and Takanobu Takezako},
  journal={Trends in Endocrinology & Metabolism},
G-protein-coupled receptors (GPCRs) are a large family of proteins that contain a seven transmembrane helical structural motif. They mediate responses to several ligands by binding and activating intracellular heterotrimeric G proteins. Since the cloning of the first GPCR, insights gained from structure-function studies, genetics and drug development have contributed to uncovering a common mechanism that explains the activation of diverse GPCRs by their cognate agonists. This mechanism takes… CONTINUE READING
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Publications referenced by this paper.
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The function of extracellular cysteines in the human adrenomedullin receptor

  • K Kuwasako
  • Hypertens. Res
  • 2003

Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist

  • V Vlaeminck-Guillem
  • Mol. Endocrinol
  • 2002

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: insights from mutations converting antagonists into agonists

  • Bessis, A.S
  • Proc. Natl. Acad. Sci. U. S. A
  • 2002