Activation of G-protein-coupled receptors: a common molecular mechanism.

  title={Activation of G-protein-coupled receptors: a common molecular mechanism.},
  author={Sadashiva S Karnik and Camelia Baleanu Gogonea and Supriya Patil and Yasser Saad and Takanobu Takezako},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={14 9},
G-protein-coupled receptors (GPCRs) are a large family of proteins that contain a seven transmembrane helical structural motif. They mediate responses to several ligands by binding and activating intracellular heterotrimeric G proteins. Since the cloning of the first GPCR, insights gained from structure-function studies, genetics and drug development have contributed to uncovering a common mechanism that explains the activation of diverse GPCRs by their cognate agonists. This mechanism takes… CONTINUE READING

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