Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain.

@article{Laoukili2008ActivationOF,
  title={Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain.},
  author={Jamila Laoukili and M{\'o}nica Alvarez and Lars A. T. Meijer and Marie Stahl and Shabaz Mohammed and Livio Kleij and Albert J. R. Heck and Ren{\'e} H Medema},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 9},
  pages={3076-87}
}
The Forkhead transcription factor FoxM1 is an important regulator of gene expression during the G(2) phase. Here, we show that FoxM1 transcriptional activity is kept low during G(1)/S through the action of its N-terminal autoinhibitory domain. We found that cyclin A/cdk complexes are required to phosphorylate and activate FoxM1 during G(2) phase. Deletion of the N-terminal autoinhibitory region of FoxM1 generates a mutant of FoxM1 (DeltaN-FoxM1) that is active throughout the cell cycle and no… CONTINUE READING

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