Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.

@article{Schett1999ActivationOF,
  title={Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.},
  author={Georg Schett and C W Steiner and Marion Groeger and Susan Winkler and Winfried Graninger and Josef S Smolen and Quing Xu and Georg Steiner},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1999},
  volume={13 8},
  pages={
          833-42
        }
}
Activation of heat shock factor (HSF) 1-DNA binding and inducible heat shock protein (hsp) 70 (also called hsp72) expression enables cells to resist various forms of stress and survive. Fas, a membrane-bound protein, is a central proapoptotic factor; its activation leads to a cascade of events, resulting in programmed cell death. These two mechanisms with contradictory functions, promoting either cell survival or death, were examined for their potential to inhibit each other's activation… CONTINUE READING
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