Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L).

@article{Huang1999ActivationOF,
  title={Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L).},
  author={David C S Huang and Michael Hahne and Michael Schroeter and Karl Frei and Adriano Fontana and Andreas Villunger and Kim Newton and J. -M. Tschopp and Andreas Strasser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 26},
  pages={14871-6}
}
Fas activation triggers apoptosis in many cell types. Studies with anti-Fas antibodies have produced conflicting results on Fas signaling, particularly the role of the Bcl-2 family in this process. Comparison between physiological ligand and anti-Fas antibodies revealed that only extensive Fas aggregation, by membrane bound FasL or aggregated soluble FasL consistently triggered apoptosis, whereas antibodies could act as death agonists or antagonists. Studies on Fas signaling in cell lines and… CONTINUE READING

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