Activation of FSH-responsive adenylate cyclase by staurosporine: role for protein phosphorylation in gonadotropin receptor desensitization.

@article{KerenTal1996ActivationOF,
  title={Activation of FSH-responsive adenylate cyclase by staurosporine: role for protein phosphorylation in gonadotropin receptor desensitization.},
  author={Iris Keren-Tal and Ada Dantes and Abraham Amsterdam},
  journal={Molecular and cellular endocrinology},
  year={1996},
  volume={116 1},
  pages={39-48}
}
Prolonged stimulation of gonadotropin receptors in granulosa cells leads to desensitization of the cellular response to gonadotropic hormones which is evident by decrease in cAMP formation. In order to explore the mechanism of desensitization and to examine whether protein phosphorylation may play a role in this phenomenon, we have studied the effect of various stimulators and inhibitors of protein phosphorylation on FSH-induced cAMP formation in the FSH-responsive cell line, GFSHR-17, recently… CONTINUE READING