Activation of FOXO 3 a by the Green Tea Polyphenol Epigallocatechin-3-Gallate Induces Estrogen Receptor A Expression Reversing Invasive Phenotype of Breast Cancer Cells

Abstract

Previously, we showed that the bioactive green tea polyphenol epigallocatechin-3-gallate (EGCG) inhibits growth in soft agar of breast cancer cells with Her-2/neu overexpression. Using gene expression profiling, here we show that EGCG treatment of Her-2/neu–driven mammary tumor cells alters the expression of key regulators in the epithelial to mesenchymal… (More)

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