Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.

@article{Xiong2013ActivationOF,
  title={Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.},
  author={Yumei Xiong and Gayathri Swaminath and Qiong Cao and Li Yang and Qi Gao Guo and Heather Salomonis and Jenny Q Lu and Jonathan B. Houze and Paul J. Dransfield and Yingcai Wang and Jiwen Jim Liu and Simon Wong and Ralf Schwandner and Franziska Steger and Helene Baribault and Lily L. Liu and Suzanne Coberly and Lynn Miao and Jane Tong Wen Zhang and Daniel C-H Lin and Margrit Schwarz},
  journal={Molecular and cellular endocrinology},
  year={2013},
  volume={369 1-2},
  pages={119-29}
}
FFA1 (GPR40) and GPR120 are G-protein-coupled receptors activated by long-chain fatty acids. FFA1 is expressed in pancreatic β-cells, where it regulates glucose-dependent insulin secretion, and GPR120 has been implicated in mediating GLP-1 secretion. We show here that FFA1 co-localizes with GLP-1 in enteroendocrine cells and plays a critical role in glucose management by mediating GLP-1 secretion in vivo. Corn oil induces GLP-1 secretion in wild type mice and in GPR120-/- mice, but not in FFA1… CONTINUE READING

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