Activation of Erk mitogen-activated protein kinase proteins by vascular serotonin receptors.

@article{Watts2001ActivationOE,
  title={Activation of Erk mitogen-activated protein kinase proteins by vascular serotonin receptors.},
  author={Stephanie W Watts and Pengyuan Y. Yang and Amy K L Banes and Melvin Baez},
  journal={Journal of cardiovascular pharmacology},
  year={2001},
  volume={38 4},
  pages={539-51}
}
We previously demonstrated that 5-hydroxytryptamine 2A (5-HT 2A ) receptor-mediated rat arterial contraction was dependent on activation of tyrosine kinases, including mitogen-activated protein kinase (MAPK) kinase. In the current study, we examined arterial smooth muscle for the presence of serotonin (5-hydroxytryptamine, 5-HT) 5-HT 1B, 5-HT 1D, 5-HT 1F, 5-HT 2A, 5-HT 2B, and 5-HT 7 receptor mRNA and hypothesized that, if present, activation of these receptors would stimulate the extracellular… CONTINUE READING
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