Activation of EphA receptors on CD4+CD45RO+ memory cells stimulates migration.

  title={Activation of EphA receptors on CD4+CD45RO+ memory cells stimulates migration.},
  author={Halvor Lauvstad Holen and Kjell Johannes Nustad and H-C Aasheim},
  journal={Journal of leukocyte biology},
  volume={87 6},
We have demonstrated previously that binding of ephrin-A1 to EphA receptors on human CD4(+) and CD8(+) T cells stimulates migration. Two EphA receptors have been reported in T cells: EphA1 at the protein level and EphA4 at the mRNA level. In this study, we wanted to investigate the expression profile of these receptors in T cell subpopulations and to test if expression differences would affect the potential of cells to migrate upon ephrin-A1 binding. We have generated an anti-EphA4 mAb for… CONTINUE READING
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