Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors.

@article{Semerdjieva2013ActivationOE,
  title={Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors.},
  author={Sophia Semerdjieva and Hayder H Abdul-Razak and Sharifah Masitah Binti Syed Salim and Rafael Joaqu{\'i}n Y{\'a}{\~n}ez-Mu{\~n}oz and Philip E. Chen and Victor Tarabykin and Pavlos Alifragis},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 7},
  pages={1442-55}
}
Regulation of the activity of N-methyl-d-aspartate receptors (NMDARs) at glutamatergic synapses is essential for certain forms of synaptic plasticity underlying learning and memory and is also associated with neurotoxicity and neurodegenerative diseases. In this report, we investigate the role of Src-like adaptor protein (Slap) in NMDA receptor signaling. We present data showing that in dissociated neuronal cultures, activation of ephrin (Eph) receptors by chimeric preclustered eph-Fc ligands… CONTINUE READING

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