Activation of Eosinophils Interacting with Bronchial Epithelial Cells by Antimicrobial Peptide LL-37: Implications in Allergic Asthma

@inproceedings{Jiao2017ActivationOE,
  title={Activation of Eosinophils Interacting with Bronchial Epithelial Cells by Antimicrobial Peptide LL-37: Implications in Allergic Asthma},
  author={Delong Jiao and Chun-Kwok Wong and Miranda Sin-Man Tsang and Ida Miu-Ting Chu and Dehua Liu and Jing Zhu and Man Yee Chu and Christopher Wai-Kei Lam},
  booktitle={Scientific Reports},
  year={2017}
}
The role of antimicrobial peptide LL-37 in asthma exacerbation is unclear. Microbial infection, which is the most common inducer of asthma exacerbation, is accompanied by elevated LL-37. The present study found that co-culture of eosinophils and bronchial epithelial cell line BEAS-2B significantly enhanced intercellular adhesion molecule-1 on both cells and CD18 expression on eosinophils upon LL-37 stimulation. IL-6, CXCL8 and CCL4 were substantially released in co-culture in the presence of LL… CONTINUE READING
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