Activation of ERAD Pathway by Human Hepatitis B Virus Modulates Viral and Subviral Particle Production

@inproceedings{Lazar2012ActivationOE,
  title={Activation of ERAD Pathway by Human Hepatitis B Virus Modulates Viral and Subviral Particle Production},
  author={Catalin Lazar and Alina Macovei and Stefana Maria Petrescu and Norica Branza-Nichita},
  booktitle={PloS one},
  year={2012}
}
Hepatitis B virus (HBV) belongs to the Hepadnaviridae family of enveloped DNA viruses. It was previously shown that HBV can induce endoplasmic reticulum (ER) stress and activate the IRE1-XBP1 pathway of the unfolded protein response (UPR), through the expression of the viral regulatory protein X (HBx). However, it remained obscure whether or not this activation had any functional consequences on the target genes of the UPR pathway. Of these targets, the ER degradation-enhancing, mannosidase… CONTINUE READING
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