Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line.

@article{Lemasson1998ActivationOE,
  title={Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line.},
  author={Isabelle Lemasson and Sabine Th{\'e}bault and Claude Sardet and Christian A. Devaux and J M Mesnard},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 36},
  pages={23598-604}
}
The human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia. Although the exact mechanism by which HTLV-I contributes to leukemogenesis is still unclear, the Tax protein is thought to play a major role in this process. This 40-kDa polypeptide is able to interact with the tumor suppressor p16(INK4A). Consequently, Tax can activate the signaling pathway that lead to the release of E2F that in turn induces expression of factors required for cell cycle progression… CONTINUE READING
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